CAS 288-32-4 Imidazole

Chemical Properties

1. Melting Point: 88-91°C (190-196°F)
2. Boiling Point: 256°C (493°F)
3. Density: 1.23 g/cm³
4. Solubility: Imidazole is highly soluble in water and solubility increases with temperature. It is also soluble in polar organic solvents such as ethanol, methanol, dimethyl sulfoxide (DMSO); slightly soluble in non-polar solvents.
5. pKa: The pKa of the imidazole ring is about 6.95, indicating that it is a weak base.

CAS 288-32-4 Applications

1. In the pharmaceutical industry,imidazole derivatives and their derivatives are employed as antifungal medications to treat fungal infections. Imidazole derivatives are utilized in the development of antihistamine medications to alleviate allergic symptoms.
2. In the field of biology

• Imidazole is commonly used as a buffer solution due to its ability to effectively maintain pH levels, particularly in the pH range of 6 to 8. It is frequently employed in the preparation of buffer solutions for investigations in biochemistry and molecular biology.
• Protein purification: Imidazole is frequently employed in affinity chromatography, particularly for the purification of histidine-tagged proteins. In this process, imidazole competes with histidine to attach to nickel ions on the affinity column.

3. Imidazole derivatives are utilized in the production of insecticides and fungicides for safeguarding crops from pests and fungal illnesses in the field of agriculture.
4. Industrial:

• Corrosion Inhibitors: Imidazole and its derivatives are employed as corrosion inhibitors in several sectors to safeguard metal surfaces from corrosion.
• Imidazole compounds serve as catalysts in the polymerisation process, facilitating the manufacture of diverse polymers and resins.

5. Imidazoles serve as intermediates in the chemical synthesis of various molecules, such as pharmaceuticals, agrochemicals, and dyes.
6. In the field of analytical chemistry, imidazole is employed as a reagent for diverse reactions and serves as an indicator for specific titrations.

Information on safety

1. Storage: It is recommended that Imidazole be stored tightly closed in a cool, dry container away from strong oxidising agents and acids. 2. 2.
2. Handling and Processing: Since CAS 288-32-4 may irritate skin and mucous membranes, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat when handling this compound. Keep the operating environment well ventilated. Wash hands thoroughly after handling.
3. First aid measures:

• In case of inadvertent skin contact, wash with plenty of soapy water and remove contaminated clothing.
• In case of inadvertent contact with eyes, flush with water and remove contact lens (if worn).
• If compound is inadvertently inhaled, keep patient in fresh air and consult a physician.

4. WASTE DISPOSAL: After all operations are completed, dispose of waste using inert materials and in accordance with local regulations.

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